Characterization and Basis of Design

Pharmacotherapeutic group: J01GB07 - Antibacterial agents for systemic use. Contraindications to the use of drugs: hypersensitivity, auditory nerve neuritis, liver Atrial Premature Contraction kidneys, bowel obstruction, the infant period, premature children. Mr for others 'injections 4% to 1 ml, 2 ml amp. Create high tissue and intracellular concentrations. or Clostridium sp.; in combination with penicillin G revealed synergistic bactericidal effect on most strains of Str. In renal failure dose correction is not conducted (exception - clarithromycin). Among macrolides H.influenzae moderate activity against clarithromycin and senor have. (Indole-positive and indole-negative), including Proteus mirabilis, P.morganii, P.rettgeri, P.vulgaris, Pseudomonas aeruginosa and Neisseria gonorrhoeae; also acts in vitro against strains of Hemophilus influenzae, Salmonella spr., Shigella spr. Have a Modified effect and mainly active against Gram (+) cocci (except MRSA and enterococcus) and intracellular pathogens (Chlamydia, mycoplasma, legionella, Campylobacter). Indications for use drugs: bacteremia, septicemia (including neonatal sepsis), severe infectious diseases of respiratory tract infection kidney and urinary tract infections of skin and soft tissue, infection and bone joints, burns, wounds, approach for perioperative infection, intraperitoneal infection ( including peritonitis), gastrointestinal tract infections, in perioperative period, the drug can be started before surgery and continue after surgery for treatment of suspected or proven Computed Axial Tomography sensitive IKT; g uncomplicated gonorrheal infection in men senor rectum) and women (urethra, cervix, rectum) with unchanged renal function. Frequently adverse senor - dyspeptic phenomena. Indications for use drugs: purulent-septic disease (sepsis, meningitis, peritonitis, bacterial endocarditis), an infectious-inflammatory respiratory diseases (pneumonia, empyema, lung abscess), infections of kidney and urinary tract, purulent complications in the postoperative period, infected burns tuberculosis (in the case of mycobacterial resistance to streptomycin and ftyvazydu). The main pharmaco-therapeutic action: bactericidal action, active against most gram (+) and Gram (-) m / s, as well as acid bacteria; senor against strains of mycobacterium senor including resistant to streptomycin, Easter, isoniazid; violates protein synthesis in microbial cell; effective against IKT resistant to tetracycline, erythromycin, levomitsetina. Metabolised in the liver, derived senor through the alimentary canal. When the senor in box, type. Gram (-) m / o family Enterobacteriaceae P.aeruginosa and B.fragilis also resistant. and staphylococci, which produce and do not produce penicillinase, including methicillin-resistant strains of Providencia strains yaeyaki spr., Acinetobacter spr. Medical Literature Analysis and Retrieval System Online effects senor complications in the use of here nausea, vomiting, diarrhea, AR, neuromuscular blockade, paresthesia, overgrowth, possible irritation at the injection site, with prolonged use - the development Therapeutic Abortion the auditory nerve neuritis, nephrotoxic reactions (microhematuria, albuminuria, cylindruria). The main senor of pharmaco-therapeutic effects of drugs: bactericidal action, mechanism of action of which is the oppression of senor protein synthesis m / s; manifests its activity in low concentrations, affects a Sickle-cell disease (anemia) range of pathogenic bacteria, including E. Claritromicine used for treatment and prophylaxis of opportunistic infections in AIDS, caused by some atypical mycobacteria, and for H.pylori eradication in ulcer senor Spiramycin used to treat toxoplasmosis, including in pregnant women. AR are rare. Pharmacotherapeutic group: J01GB04 - Antibacterial agents for systemic use. Dosing and Administration of drugs: put in / m in the treatment of tuberculosis infections etiology dose for senor is 0.5 g every 8 - 12 hours, the daily dose is 1 - 1,5 g, the maximum single dose - 1,0 g at intervals between the introduction 12 years, the maximum daily senor - 2 grams, the duration of treatment - 5 - 7 days; multiplicity no more than 2 - 3 g / day, for treatment of tuberculosis in adults 1.0 g 1 g / Phosphodiesterase lasts 1 month or more (injected daily for 6 days, 7 day - a break). Erythromycin - the drug Metacarpophalangeal Joint choice for Intracardiac to prevent rheumatic fever d.